Wacthing P+ and Tom talking about Allen hopefully being back soon, I started trying to think of the last time a "major" GS had a substitute host that wasn't part of a "stunt." (By "major" I mean one that's generally known and probably network/syndie, not some community-access show in Windswept Acres, Nebraska. And a "stunt" is like host-swap day on GSN.)
These days, if a host is unavailable, production just simply shuts down and repeats are aired if needed, yes?
I'll open the bidding with Jim Peck on TJW, 1984.
Edit to add: Of course J! and Wheel are current/recent; I guess my mind stopped working in 2000.