Seems that panel shows have either fallen out of favor in this fast-paced world, or the right producer just hasn't figured out how to do one. With the oddball news stories out there, I could see it working. Then again, with sites like Youtube making people "celebrities" (see Dodson, Antoine and Crocker, Chris), it might make for quite a few disqualified panelists. ;-)
I've Got a Secret was tried twice in the last decade, and neither caught on. I thought the GSN version was pretty decent, but I think it tried to reach too far with the retro kitsch.
Then again, I'm surprised The Newlywed Game has made it in the 2000s. Maybe GSN could try a new TTTT, in the same vein as IGAS, but drop the kitsch.